TRANSCRIPTOME PROFILING IDENTIFIES GENES AND PATHWAYS DEREGULATED UPON FLOXURIDINE TREATMENT IN COLORECTAL CANCER CELLS HARBORING GOF MUTANT P53

Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Mutation in TP53 is a common genetic alteration in human cancers.Certain tumor associated p53 missense mutants acquire gain-of-function (GOF) properties and confer oncogenic phenotypes including enhanced chemoresistance.The colorectal cancers (CRC) harboring mutant p53 are generally aggressive in nature and difficult to treat.To identify a potentia

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Barriers to the Quality of Emergency Online Pedagogies in Higher Education during the COVID-19 Pandemic: A Case Study from the University of Namibia

Using the TIPEC framework, this study undertook a critical literature analysis, and student survey to explore challenges experienced by higher education institutions during emergency online pedagogies because of disruptions from the COVID-19 outbreak.The study revealed that most higher education institutions are still grappling with getting technic

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Comparison of depression and anxiety symptom networks in reporters and non-reporters of lifetime trauma in two samples of differing severity

Background: Reported trauma is associated with differences in the course and outcomes of depression and anxiety.However, no research has explored the association between reported trauma and patterns of clinically relevant symptoms of both depression and anxiety.Methods: We used ps5 for sale las vegas network analysis to investigate associations bet

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